Effect of B vitamin supplementation on plasma homocysteine levels in celiac disease

Table 2 Serum vitamin B6, folate, vitamin B12 and plasma homocysteine levels in patients with celiac disease (without and with regular vitamin supplements) and in healthy controls

Variable	Healthy controls (n = 50)	Patients with celiac disease not using vitamins (n = 26)	Patients with celiac disease using vitamins (n = 25)	P1
Median vitamin B6 (interquartile range), nmol/L	39.0 (30.2-54.2)	36.0 (21.0-77.2)	74.0 (28.0-183.5)	0.016
Median folate (interquartile range), nmol/L	9.7 (7.2-12.5)	12.1 (7.2-16.5)	29.9 (14.9-57.0)	< 0.001
Median vitamin B12 (interquartile range), pmol/L	234.5 (190.0-277.5)	230.5 (176.5-299.0)	342.0 (208.0-536.5)	0.017
Median homocysteine (interquartile range), &mgr;mol/L	9.7 (8.4-11.9)	11.0 (9.2-14.3)	7.1 (6.2-10.7)	0.001
Villous atrophy, n%		14 (54.0%)	12 (48.0%)	0.78

¹Continuous data were compared by Kruskall-Wallis test and categorical data were compared by Fisher’s exact test (two-sided).