Angiotensin-receptor blockers as therapy for mild-to-moderate hypertension-associated non-alcoholic steatohepatitis

doi:10.3748/wjg.15.942

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Feb 28, 2009 (publication date) through Nov 27, 2024

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Times Cited (137)

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Feb 28, 2009; 15(8): 942-954
Published online Feb 28, 2009. doi: 10.3748/wjg.15.942

Table 1 Demographics and baseline data at inclusion (mean ± SE)

	Units	Overall patients	Group		P
	Units	Overall patients	T	V
No. of patients		54	28	26	P	NS
Gender	Male/female	28/26	14/14	12/14	NS
Age	yr	48.89 ± 1.41	48 ± 1.98	49.85 ± 2.05	NS
BMI (V1)	kg/m²	27.42 ± 0.36	27.21 ± 0.51	27.65 ± 0.53	NS
dBP (V1)	mmHg	101.65 ± 1.05	101.43 ± 1.17	101.89 ± 1.8
sBP (V1)	mmHg	156.53 ± 1.28	155.71 ± 1.61	157.42 ± 2.04
ALT (V1)	IU/L	67.65 ± 2.01	66.96 ± 2.95	68.38 ± 2.75	NS
AST (V1)	IU/L	70.31 ± 2.34	72.78 ± 3.53	67.65 ± 3.02
GGT (V1)	IU/L	23.85 ± 1.62	22.60 ± 2.37	25.19 ± 2.22
B (V1)	mg/dL	0.89 ± 0.02	0.9 ± 0.03	0.88 ± 0.04
HOMA IR (V1)	units	7.7 ± 0.24	7.81 ± 0.40	7.58 ± 0.25
IRI (V1)	&mgr;U/mL	27.64 ± 0.86	27.78 ± 1.14	27.50 ± 1.32
FPG (V1)	mg/dL	113.83 ± 1.98	113.60 ± 2.77	114.07 ± 2.88
HDL-C (V1)	mg/dL	42.44 ± 1.2	42.34 ± 1.68	42.54 ± 1.77	NS¹
		M: 37.8 ± 1.38	M: 37.45 ± 1.86	M: 38.16 ± 2.11
		F: 47.42 ± 1.5	F: 47.23 ± 2.13	F: 47.66 ± 2.19
TC (V1)	mg/dL	196.46 ± 1.13	196.07 ± 1.5	196.88 ± 1.73	NS¹
		M: 200.82 ± 1.2	M: 200.57 ± 1.29	M: 201.07 ± 2.07
		F: 191.77 ± 1.5	F: 191.57 ± 2.13	F: 192 ± 2.19
TG (V1)	mg/dL	161.51 ± 4.91	165.64 ± 6.95	157.08 ± 7.18
NAS (V1)	points	5.89 ± 0.14	6 ± 0.18	5.77 ± 0.22	NS
Steatosis (V1)		2.16 ± 0.09	2.21 ± 0.12	2.11 ± 0.16
Lobular inflammation (V1)		1.70 ± 0.06	1.68 ± 0.09	1.73 ± 0.09
Ballooning (V1)		2.02 ± 0.1	2.11 ± 0.13	1.92 ± 0.16
Fibrosis (V1)	points	2.11 ± 0.11	2.07 ± 0.16	2.15 ± 0.15	NS

BMI: Body mass index; dBP: Diastolic blood pressure; sBP: Systolic blood pressure; ALT: Alanine-aminotransferase; AST: Aspartate-aminotransferase; GGT: Gamma-glutamyl transpeptidase; B: Bilirubin; HOMA-IR: Homeostasis model assessment index for insulin-resistance; IRI: Plasma immunoreactive insulin; FPG: Fasting plasma glucose; TC: Total cholesterol; HDL-C: High density lypoprotein-cholesterol; TG: Triglycerides; NAS: NASH activity score; M: Male patients; F: female patients; V1: index data at visit 1;

¹Statistics performed depending on gender and also in overall patients.

Citation: Georgescu EF, Ionescu R, Niculescu M, Mogoanta L, Vancica L. Angiotensin-receptor blockers as therapy for mild-to-moderate hypertension-associated non-alcoholic steatohepatitis. World J Gastroenterol 2009; 15(8): 942-954
URL: https://www.wjgnet.com/1007-9327/full/v15/i8/942.htm
DOI: https://dx.doi.org/10.3748/wjg.15.942