Excretion of biliary compounds during intrauterine life

Figure 1 The foetal liver-placenta-maternal liver excretory pathway. Schematic representation of transporters (NTCP, sodium-taurocholate co-transporting polypeptide; OATP: Organic anion-transporting polypeptide), ATP-dependent pumps (BCRP: Breast cancer resistance protein; BSEP: Bile salt export pump; MDR: Multidrug resistance protein; MRP: Multidrug resistance-associated protein), and phase I (ALDH: Aldehyde dehydrogenase; BVR: Biliverdin reductase; CYP: Cytochrome P450 enzyme; HO: Heme oxygenase) and II (EH: Epoxide hydrolase; GST: Glutathione-S-transferase; NAT: N-acetyltransferase; ST: Sulfotransferase; UGT: UDP-glucuronosyl transferase) enzymes involved in excretion of biliary compounds during intrauterin life.