Epigenetics of proteasome inhibition in the liver of rats fed ethanol chronically

doi:10.3748/wjg.15.705

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Feb 14, 2009 (publication date) through Dec 2, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Feb 14, 2009; 15(6): 705-712
Published online Feb 14, 2009. doi: 10.3748/wjg.15.705

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Figure 4 Role of proteasome inhibition in the remethylation pathway. A: Proteasome inhibition by PS-341 (PS) markedly decreased BHMT gene expression; B: Real time PCR analysis of BHMT expression; C: Western blot analysis of BHMT level in the liver of rats fed ethanol chronically and the liver of rats given PS-341. Note that the BHMT level was significantly reduced in the liver of rats treated with PS-341; D: Proteasome inhibition caused a decrease in histone methylation.

Citation: Oliva J, Dedes J, Li J, French SW, Bardag-Gorce F. Epigenetics of proteasome inhibition in the liver of rats fed ethanol chronically. World J Gastroenterol 2009; 15(6): 705-712
URL: https://www.wjgnet.com/1007-9327/full/v15/i6/705.htm
DOI: https://dx.doi.org/10.3748/wjg.15.705