Pediatric liver transplantation

Table 7 Literature review of immunosuppressive protocol with steroid weaning after pediatric liver transplantation

Author	Year	Patients (n)	Protocol	Weaning (%)		Graft loss	Rejection (%)
				Performed	Success		Acute	Chronic
Margarit et al[110]	1989	18	CsA+Aza	83	61	13%	27	13
Andrews et al[111]	1994	119	CsA+Aza1	44	67	No	13	No
Dunn et al[112]	1994	73	CsA+Aza	51	76	4%	7	4
McDiarmid et al[113]	1995	13	CsA+Aza			No	No	No
McKee et al[114]	1997	29	TAC	83	71		29
Martin et al[115]	1998	55	CsA+Aza	44	76	No	11	No
Reding et al[109116]	2000	375	CsA (n = 23)		21	No	No	No
			CsA-ME (n = 24)			No	No	No
			TAC (n = 31)			No	10	No
Atkison et al[117]	2002	94	CsA+Aza2	71	91		21
Toyoki et al[118]	2004	8	TAC	100	100	No	13	No

CsA: Cyclosporine; CsA-ME: Cyclosporine microemulsion; Aza: Azathioprine; TAC: Tacrolimus.

¹In 53% of the weaned children;

²Some patients received antilymphocyte globulin or OKT3 induction.