Hepatic non-parenchymal cells and extracellular matrix participate in oval cell-mediated liver regeneration

Figure 1 Ov-6 immunoreactivity of ductular cell reaction following PH of rats treated with AAF. A: Oval cells (short arrow) close to hepatocytes at limiting plates on day 2 after PH show much lighter labeling than pre-existing bile duct cells (long arrow) (× 200); B: On day 4 after PH, strongly stained cells are beginning to move into the parenchyma (× 200); C: On day 9 after PH, apparent long cords of ductular oval cells are fanning outward from each portal area (× 100); D: On day 15, the ov-6 (+) ductular structures are restricted to the periphery of small hepatocyte nodus (× 100).