Biochemical markers for non-invasive assessment of disease stage in patients with primary biliary cirrhosis

Table 1 Values of biochemical markers and results of statistical analyses for differentiation of disease stage in patients with PBC

	mean ± SD	Range	Sensitivity (%)	Specificity (%)	Confidential interval	Area under ROC	Spearman’s rho	P value
Aspartate aminotransferase (AST) (U/L)	69.41 ± 84.7	14-466	42.5	62.5	27.8-63.3	0.484	0.303	< 0.05
Alanine aminotransferase (ALT) (U/L)	87.39 ± 105.89	13-594	40	50	30.7-60.6	0.455	0.232	NS
Albumin	37.67 ± 4.69	27-47	27.5	62.5	23.8-54.3	0.391	0.117	NS
ALT to platelet ratio (APRI)	0.39 ± 0.42	0.06-2.16	42.5	50	23.7-58.7	0.412	0.351	< 0.01
AST to platelet ratio	0.33 ± 0.38	0.06-1.70	32.5	50	19.2-53.1	0.362	0.407	< 0.01
AST/ALT ratio	0.81 ± 0.23	0.51-1.38	47.5	75	17.0-50.3	0.660	0.347	< 0.01
ALT/AST ratio	1.32 ± 0.34	0.73-1.97	32.5	62.5	49.2-82.9	0.337	-0.297	< 0.05
ALT/ alkaline phosphatase (AF) ratio	0.42 ± 0.44	0.10-2.44	35	42.8	34.0-70.8	0.594	0.094	NS
ALT/gama glutamyl transferase (GGT) ratio	0.68 ± 0.94	0.12-5.09	40	56.2	33.0-67.0	0.502	0.38	NS
ALT/cholesterol (Chol) ratio	13.65 ± 10.87	2.5-59.76	35	50	26.0-61.6	0.438	0.285	< 0.05