Performance value of high risk factors in colorectal cancer screening in China

Table 4 Comparison of the performance of high risk factors in screening advanced neoplasias, adenomas, non-adenomatous polyps using HAP as reference

	Advanced neoplasias				Adenomas				Non-adenomatous polyps
	PPV (%)	NPV (%)	RSN	FP:TP	PPV (%)	NPV (%)	RSN	FP:TP	PPV (%)	NPV (%)	RSN	FP:TP
iFOBT	17.70	95.70	4.9 (2.42-9.87)	2.29 (1.36-3.83)	22.50	85.10	2.24 (1.4-3.52)	2.58 (1.37-4.87)	4.40	93	1.8 (0.71-4.58)	16 (3.39-75.58)
HMT	6.10	91.70	0.4 (0.17-1.19)		13.60	82.60	0.36 (0.18-0.7)		10.60	94	1.17 (0.39-3.48)
FDR	5.70	91.30	1 (0.4-2.519)		18.50	83.20	1.16 (0.69-1.96)	8.25 (0.44-154.47)	7	93.90	1.8 (0.67-4.88)	6.6 (1.16-37.6)
HAP	9.40	92	1		26	84	1		6.30	93.70	1
MBS	5.70	91.30	1 (0.42-2.39)		9.50	81.20	0.6 (0.33-1.08)		6.30	93.70	1.7 (0.66-4.38)	13.25 (2.02-86.77)
HCD	5.40	91	1.2 (0.54-2.63)	24 (1.87-307.35)	13.90	82	1.16 (0.72-1.88)	18 (1.1-293.1)	4.90	93.30	1.7 (0.71-4.08)	18 (3.2-101.33)
HCC	4.80	91	0.9 (0.35-2.33)		14.30	82.20	0.96 (0.56-1.65)		7.70	94.10	2.2 (0.88-5.49)	7.7 (2.26-26.21)
CAA	5.50	91	1.3 (0.59-2.83)	24.6 (1.63-370.18)	15.10	82.20	1.32 (0.8-2.16)	9.25 (1.52-55.7)	6.40	93.80	2.3 (0.88-5.99)	9.25 (2.96-28.79)
CCC	5.80	87.40	1.9 (0.87-4.12)	15.13 (4.47-51.23)	16.90	82.80	2 (1.26-3.16)	4.84 (2.43-9.65)	6.40	93.80	3.2 (1.38-7.42)	9.3 (4.5-19.22)
HPT	7.60	91.80	1 (0.42-2.39)		15.30	82.60	0.72 (0.43-1.2)		1.70	93	0.33 (0.07-1.63)

HMT: History of malignant tumor; FDR: History of CRC in first degree relatives; MBS: History of mucous and bloody stool; HCD: History of chronic diarrhea; HCC: History of chronic constipation; CAA: History of chronic appendicitis or appendectomy; CCC: History of chronic cholecystitis or cholecystectomy; HPT: History of psychiatric trauma; PPV: Positive predictive value; NPV: Negative predictive value; RSN: Relative sensitivity; FP:TP ratio: The ratio between the difference in the number of false positive subjects with one high risk factor vs HAP and the difference in the number of true positive subjects with one high risk factor vs HAP. Values for RSN and FP:TP are mean (95% CI). RSN > 1: Sensitivity of the high risk factor is greater than that of HAP.