Effect of severe acute pancreatitis on pharmacokinetics of Da-Cheng-Qi Decoction components

Table 4 Twelve-hour pharmacokinetic parameters of DCQD components in rats of the two groups (n = 6)

	T1/2α (h)	AUC(0-∞) (μg/L per hour)	MRT(0-t) (h)	Tmax (h)	Cmax (μg/L)
Magnolol
Sham	1.58 ± 1.06	24.89 ± 9.87	6.6 ± 1.85	0.71 ± 0.25	3.47 ± 2.13
AP	1.11 ± 0.48	5.739 ± 1.888	9.202 ± 2.27	0.428 ± 0.282	1.491 ± 0.596
t	1.0821	4.6204	2.2156	1.8329	2.2431
P	0.3046	0.001	0.0511	0.0967	0.0487
Hesperidin
Sham	0.45 ± 0.25	479.39 ± 225.94	5.62 ± 2.45	0.67 ± 0.13	89.38 ± 25.02
AP	0.69 ± 0.36	162.98 ± 69.76	4.93 ± 2.233	1.25 ± 0.59	53.7 ± 22.026
t	1.3413	3.2953	0.5133	2.3141	2.5744
P	0.2095	0.0081	0.6189	0.0432	0.0277
Naringin
Sham	1.47 ± 1.57	623.24 ± 332.55	6.43 ± 2.1	0.64 ± 0.24	88.23 ± 23.66
AP	1.1 ± 0.7	267.68 ± 53.65	7.12 ± 1.96	0.83 ± 0.13	45.13 ± 9.59
t	0.5272	2.5852	0.5659	1.732	4.0511
P	0.6095	0.0272	0.5839	0.1139	0.0023