Effect of severe acute pancreatitis on pharmacokinetics of Da-Cheng-Qi Decoction components

Table 3 Twelve-hour pharmacokinetic parameters of DCQD components in rats of the two groups (n = 6)

	T1/2α (h)	CL/F (L∙h per kg)	AUC(0-∞) (μg/L per hour)	MRT(0-t) (h)	Tmax (h)	Cmax (μg/L)
Rhein
Sham	0.33 ± 0.13	4.03 ± 1.38	4720 ± 1514	8.86 ± 0.62	0.36 ± 0.11	510 ± 283
AP	4.367 ± 2.33	0.133 ± 0.06	2870 ± 563	7.82 ± 3.37	1.75 ± 1.25	479 ± 126
t	4.2721	6.9106	2.8054	0.7513	2.7242	0.2448
P	0.0016	0	0.0186	0.4698	0.0214	0.8116
Rheochrysidin
Sham	0.354 ± 0.302	0.356 ± 0.14	16.047 ± 6.08	4.189 ± 0.463	0.569 ± 0.26	3.86 ± 1.09
AP	1.464 ± 0.449	0.328 ± 0.109	16.63 ± 5.06	4.34 ± 0.29	1.5 ± 0.55	2.58 ± 0.58
t	5.0247	0.3866	0.179	0.6929	3.7597	2.5511
P	0.0005	0.7072	0.8615	0.5041	0.0037	0.0288
Chrysophanol
Sham	0.38 ± 0.27	24.32 ± 9.65	461.3 ± 188.7	8.49 ± 0.93	0.59 ± 0.24	53.02 ± 21.9
AP	0.89 ± 0.48	0.095 ± 0.035	115.8 ± 34.89	10 ± 5.1	1.33 ± 0.52	17.59 ± 10.5
t	2.2683	6.0994	4.3965	0.7088	3.165	3.4855
P	0.0467	0.0001	0.0013	0.4947	0.0101	0.0059