Role of the receptor for advanced glycation end products in hepatic fibrosis

Figure 4 AGE do not stimulate DNA synthesis in hepatic stellate cells. DNA synthesis as a surrogate of proliferation was determined in CFSC-2G (A) and HSC-T6 (B) HSC after a 24 h incubation with increasing concentrations of FCS, AGE-BSA or CML-BSA in 0% FCS. Data are results of six independent experiments and expressed as mean ± SD. ^aP < 0.05, ^dP < 0.001 vs 0% FCS.