Nicotinamide overload may play a role in the development of type 2 diabetes

doi:10.3748/wjg.15.5674

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Dec 7, 2009 (publication date) through Jan 11, 2025

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Dec 7, 2009; 15(45): 5674-5684
Published online Dec 7, 2009. doi: 10.3748/wjg.15.5674

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Figure 1 Urinary excretion patterns of 2Py and N¹-methylnicotinamide in diabetic and non-diabetic subjects. A and B: Representative HPLC chromatograms of urinary excretions of 2Py (indicated by arrow) and N¹-methylnicotinamide (NMN) of a non-diabetic (Aa and Ba) and a diabetic (Ab and Bb) subject, before and after 100 mg nicotinamide loading at 7:00 am Urine samples taken at given time were normalized to equal volumes before HPLC analysis; C and D: Summaries of the results from the measurements shown in A and B, respectively. Bar graphs indicate mean ± SD.

Citation: Zhou SS, Li D, Sun WP, Guo M, Lun YZ, Zhou YM, Xiao FC, Jing LX, Sun SX, Zhang LB, Luo N, Bian FN, Zou W, Dong LB, Zhao ZG, Li SF, Gong XJ, Yu ZG, Sun CB, Zheng CL, Jiang DJ, Li ZN. Nicotinamide overload may play a role in the development of type 2 diabetes. World J Gastroenterol 2009; 15(45): 5674-5684
URL: https://www.wjgnet.com/1007-9327/full/v15/i45/5674.htm
DOI: https://dx.doi.org/10.3748/wjg.15.5674