Peutz-Jeghers syndrome: Diagnostic and therapeutic approach

Table 2 Cancer screening in PJS patients[13-17,22]

Site of possible tumour	Age of screening initiation	Periodicity	Method of screening
Colon	15 yr1	2 yr2	Colonoscopy, CA 19-9
Oral parts of GIT	15 yr1	2 yr2	Gastroscopy
Small intestine	15 yr1	2 yr2	Capsule enteroscopy or MRI scan
Breast	21 yr	Monthly	Self-examination
		6-12 mo	Sonography or mammography, CA 125
Thyroid gland	18 yr	1 yr	Sonography, clinical examination
Pancreas	18 yr	1 yr	Sonography or CT or MRI scan
Uterus and ovaria	18 yr	1 yr	Sonography, clinical examination
Testes	18 yr	1 yr	Sonography, clinical examination
Lung	18 yr	5 yr?	X-ray, clinical examination

¹Earlier in symptomatic persons;

²Endoscopy each year as long as polyps are present, subsequently prolong intervals. PJS: Peutz-Jeghers syndrome.