Modification of sleep architecture in an animal model of experimental cirrhosis

Table 1 CCl₄ effect on sleep architecture for 11 wk of treatment (min) (mean ± SE)

Treatment	Wake total time	SWS I total time	SWS II total time	REM sleep total time	Duration of REM sleep epochs	Frequency of REM sleep	Latency of REM sleep	Latency of SWS
Control (n = 10)	169.03 ± 14.94	89.67 ± 9.21	174.82 ± 9.516	42.32 ± 5.47	2.16 ± 0.21	17.3 ± 1.315	48.84 ± 11.54	37.06 ± 6.78
1 wk (n = 10)	142.93 ± 9.21	109.69 ± 12.89	158.40 ± 13.32	67.64 ± 4.89b	2.95 ± 0.27	23 ± 2.27	69.7 ± 26.61	25.60 ± 6.05
2 wk (n = 10)	128.85 ± 9.74b	87.45 ± 8.45	213.62 ± 6.07a	49.52 ± 7.39	2.56 ± 0.14	17.7 ± 1.93	80.27 ± 19.98	26.57 ± 5.58
3 wk (n = 9)	133.40 ± 9.26a	74.36 ± 14.90	214.38 ± 18.94a	57.30 ± 5.44	2.44 ± 0.13	22.22 ± 1.98	51.45 ± 16.44	18.99 ± 4.43
4 wk (n = 9)	107.77 ± 11.07b	80.69 ± 10.27	225.89 ± 10.20b	58.60 ± 7.94a	2.44 ± 0.160	22.22 ± 2.17	63.80 ± 17.81	17.84 ± 3.41
5 wk (n = 9)	107.52 ± 12.58b	74.27 ± 13.55	232.54 ± 14.85b	67.24 ± 5.45b	2.70 ± 0.27	23.55 ± 1.74	73.67 ± 19.52	25.04 ± 4.98
6 wk (n = 7)	121.19 ± 11.64b	86.08 ± 8.86	208.17 ± 16.42	63.64 ± 3.37a	2.72 ± 0.26	22.42 ± 2.01	79.99 ± 18.22	17.58 ± 2.30
7 wk (n = 7)	126.87 ± 7.28b	93.07 ± 10.69	191.5 ± 13.90	61.47 ± 8.03a	2.31 ± 0.21	24.85 ± 3.47	71.49 ± 23.91	19.81 ± 4.54
8 wk (n = 7)	99.64 ± 12.18b	82.11 ± 8.89	230.48 ± 14.96b	66.93 ± 9.00b	1.96 ± 0.23	31.42 ± 2.17b	75.81 ± 11.97	18.08 ± 4.95
9 wk (n = 6)	120.06 ± 17.93b	78.53 ± 7.85	215.29 ± 16.85a	65.41 ± 3.90a	2.56 ± 0.40	24.33 ± 2.78	85.26 ± 32.18	20.03 ± 6.91
10 wk (n = 5)	82.03 ± 8.25b	66.91 ± 13.22	256.29 ± 22.37b	68.89 ± 3.72b	2.60 ± 0.50	26.6 ± 2.56b	60.46 ± 36.58	17.15 ± 7.64
11 wk (n = 5)	72.79 ± 11.77b	77.34 ± 17.61	257.84 ± 18.77b	71.28 ± 7.67b	2.63 ± 0.41	26.4 ± 2.56b	39.64 ± 10.70	17.24 ± 5.22

^aP < 0.05,

^bP < 0.01 vs control. Repeated measure ANOVA.