Patient-reported outcomes in subjects with neuroendocrine tumors of the pancreas

Table 3 Effects of neuroendocrine tumors of the pancreas on the STAI Y-1 (anxiety state) and Y-2 (anxiety trait) estimated by means of three-way ANOVA adjusted for age (increasing trend among the age classes) and gender

	STAI anxiety state (Y-1)		STAI anxiety trait (Y-2)
	Effects (95% CI)	P value	Effects (95% CI)	P value
Overall effects of the disease (patients vs normative group)	-5.16 (-12.56 to 2.23)	0.169	0.77 (-5.84 to 7.39)	0.817
Effects of the disease within males	-4.66 (-16.98 to 7.67)	0.454	-0.48 (-11.50 to 10.54)	0.932
Effects of the disease within females	-5.66 (-13.84 to 2.51)	0.172	2.02 (-5.29 to 9.33)	0.584
Interaction between the effects of the disease and gender (males vs females)	1.00 (-13.79 to 15.79)	0.893	-2.50 (-15.72 to 10.73)	0.708
Interaction between the effects of the disease and age	7.69 (-7.10 to 22.48)	0.304	-2.58 (-15.81 to 10.64)	0.698
Interaction between the effects of the disease and age within males	5.30 (-19.35 to 29.95)	0.670	-0.05 (-22.09 to 21.99)	0.996
Interaction between the effects of the disease and age within females	10.07 (-6.28 to 26.42)	0.224	-5.12 (-19.74 to 9.51)	0.488
Interaction between the effects of the disease and age and gender	-4.77 (-34.35 to 24.81)	0.749	5.06 (-21.39 to 31.51)	0.704