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©2009 The WJG Press and Baishideng.
World J Gastroenterol. Oct 28, 2009; 15(40): 5058-5066
Published online Oct 28, 2009. doi: 10.3748/wjg.15.5058
Published online Oct 28, 2009. doi: 10.3748/wjg.15.5058
Table 6 Non-haematological toxicity and UGT1A1 status (per cycle analysis) cycles (%)
| WT (6/6) | (6/7, 7/7) | χ² test | |||||
| Grade 0 | Grade 1-2 | Grade 3-4 | Grade 0 | Grade 1-2 | Grade 3-4 | ||
| Nausea | 35 (30.9) | 77 (68.1) | 1 (0.9) | 69 (35.8) | 122 (63.2) | 2 (1.0) | P > 0.05 |
| Vomiting | 77 (68.1) | 35 (31.0) | 1 (0.9) | 123 (63.7) | 69 (35.8) | 1 (0.5) | P > 0.05 |
| Diarrhoea early | 81 (71.7) | 30 (26.5) | 2 (1.8) | 149 (77.2) | 42 (21.8) | 2 (1.0) | P > 0.05 |
| Diarrhoea delayed | 51 (45.1) | 55 (48.7) | 7 (6.2) | 78 (40.4) | 90 (46.6) | 25 (13.0) | P > 0.05 |
| Mucositis | 97 (85.8) | 16 (14.2) | - | 160 (82.9) | 31 (16.1) | 2 (1.0) | P > 0.05 |
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Citation: Schulz C, Heinemann V, Schalhorn A, Moosmann N, Zwingers T, Boeck S, Giessen C, Stemmler HJ.
UGT1A1 gene polymorphism: Impact on toxicity and efficacy of irinotecan-based regimens in metastatic colorectal cancer. World J Gastroenterol 2009; 15(40): 5058-5066 - URL: https://www.wjgnet.com/1007-9327/full/v15/i40/5058.htm
- DOI: https://dx.doi.org/10.3748/wjg.15.5058