Endoscopic features predictive of gastric cancer in superficial lesions with biopsy-proven high grade intraepithelial neoplasia

Figure 1 A case of true HGIEN of gastric mucosa. A: Endoscopic view of a sessile polypoid lesion (types 0-I) in the greater curvature of gastric corpus. The lesion is approximately 1.2 cm in size with a smooth contour. Biopsy pathology indicated high grade intraepithelial neoplasia; B: Low-power view of the en-bloc resected specimen, showing negative vertical and horizontal margins (HE staining, × 25); C: High-power view shows prominent cellular atypia and increased proliferative activity without stromal invasion, indicating high grade intraepithelial neoplasia (HE staining, × 200).