Midkine translocated to nucleoli and involved in carcinogenesis

Figure 2 Nuclear targeting by growth factor MK. MK was endocytosed into cell cytosol through binding to the receptor of LRP, and then tanslocated to nuclei in the presence of nucleulin or LBP. At the same time, the internalized MK is degraded by proteasome to “off” the signals from the cell surface receptors.