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©2009 The WJG Press and Baishideng.
World J Gastroenterol. Jan 28, 2009; 15(4): 478-483
Published online Jan 28, 2009. doi: 10.3748/wjg.15.478
Published online Jan 28, 2009. doi: 10.3748/wjg.15.478
Table 1 Grading system used for histological parameters: cholestasis, eosinophilia in the inflammatory infiltrate, presence of giant cells, erythropoiesis, siderosis, and portal fibrosis
Mild | Moderate | Severe | |
Cholestasis | Biliary pigment deposits in few hepatocytes of zone 3 acini | Hepatocytes with biliary pigment in two zone 3 acini associated with the presence of rare canalicular bilirubinostasis | The majority of the hepatocytes with biliary pigment biliary associated with several canalicular bilirubinostasis |
Eosinophilia in the inflammatory infiltrate | Rare eosinophils in few space-porta | Some eosinophils in many space-porta and rare in the parenchyma | Many eosinophils in all the space-porta and several in the parenchyma |
Presence of giant cells | Occurring in a maximum of 30% of the hepatocytes | Between 30% and 60% of the hepatocytes | > 60% of the hepatocytes |
Erythropoiesis | Rare groupings of erythroblasts | Some groupings of erythroblasts | Groupings of erythroblasts and megakaryocytes |
Siderosis | Deposits of ferric pigment in only a few Kupffer cells | Deposits of ferric pigment in Kupffer cells and a few hepatocytes | Deposits of ferric pigment in the majority of Kupffer cells and many hepatocytes |
Portal fibrosis | Discrete widening of some space-porta | Widening of some space-porta | Widening of all space-porta |
- Citation: Bellomo-Brandao MA, Escanhoela CA, Meirelles LR, Porta G, Hessel G. Analysis of the histologic features in the differential diagnosis of intrahepatic neonatal cholestasis. World J Gastroenterol 2009; 15(4): 478-483
- URL: https://www.wjgnet.com/1007-9327/full/v15/i4/478.htm
- DOI: https://dx.doi.org/10.3748/wjg.15.478