Short-term Celecoxib intervention is a safe and effective chemopreventive for gastric carcinogenesis based on a Mongolian gerbil model

doi:10.3748/wjg.15.4907

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Oct 21, 2009; 15(39): 4907-4914
Published online Oct 21, 2009. doi: 10.3748/wjg.15.4907

Table 1 Effect of Celecoxib treatment period on incidence of gastric cancer in Mongolian gerbils

Group	Regimen	Period of Celecoxibtreatment (wk)	n	Rate of gastric cancer(%)	Type of cancer
Group	Regimen	Period of Celecoxibtreatment (wk)	n	Rate of gastric cancer(%)	Well	Poor	Sig
A	HP+MNNG	0	20	40 (8/20)	8	0	0
B	HP+MNNG+Celecoxib	30	20	0 (0/20)^a	0	0	0
C	HP+MNNG+Celecoxib	20	20	0 (0/20)^a	0	0	0
D	HP+MNNG+Celecoxib	20	20	20 (4/20)	4	0	0
E	HP+MNNG+Celecoxib	15	20	25 (5/20)	5	0	0
F	Vehicle	0	12	0	0	0	0

HP: H pylori (intra-gastric); MNNG: N’-methyl-N’-nitro-N-nitroso-guanidine; Well: Well-differentiated adenocarcinoma; Poor: Poorly differentiated adenocarcinoma; Sig: Signet-ring cell carcinoma.

^aP < 0.05 vs group A.

Citation: Kuo CH, Hu HM, Tsai PY, Wu IC, Yang SF, Chang LL, Wang JY, Jan CM, Wang WM, Wu DC. Short-term Celecoxib intervention is a safe and effective chemopreventive for gastric carcinogenesis based on a Mongolian gerbil model. World J Gastroenterol 2009; 15(39): 4907-4914
URL: https://www.wjgnet.com/1007-9327/full/v15/i39/4907.htm
DOI: https://dx.doi.org/10.3748/wjg.15.4907