Decreased expression of Neurensin-2 correlates with poor prognosis in hepatocellular carcinoma

Table 1 Correlations between NRSN2 expression and clinicopathologic variables of 110 cases of HCC

Clinicopathologic variables	n	NRSN2 expression		χ2	P-value
		Negative	Positive
All cases	110	32	78
Age				0.037	0.848
< 50	60	43	17
≥ 50	50	35	15
Gender				0.341	0.559
Female	14	9	5
Male	96	69	27
Tumor size (cm)				7.678	0.006a
< 5	37	20	17
≥ 5	73	58	15
Histological differentiation				0.879	0.258
Well	18	12	6
Moderate	69	49	20
Poor	23	17	5
Liver cirrhosis				0.176	0.675
Yes	55	38	17
No	55	40	15
Metastasis				0.152	0.697
Yes	16	12	4
No	94	66	28
HBsAg status				3.400	0.065
Positive	96	71	25
Negative	14	7	7
Serum AFP (μg/L)				0.360	0.549
Positive (≥ 25)	80	58	22
Negative (< 25)	30	20	10

^aP < 0.05. NRSN2: Neurensin-2; HCC: Hepatocellular carcinoma.