Hepatoprotective evaluation of Anogeissus latifolia: In vitro and in vivo studies

doi:10.3748/wjg.15.4816

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Oct 14, 2009 (publication date) through Jul 29, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Oct 14, 2009; 15(38): 4816-4822
Published online Oct 14, 2009. doi: 10.3748/wjg.15.4816

Table 1 Effect of Anogeissus latifolia extract (ALE) on CCl₄-induced toxicity in rat hepatocytes (mean ± SE)

Treatment	Viable cells (%)	ALT (IU/L)	AST (IU/L)
Cell control	93.88 ± 0.81	18.70 ± 0.46	21.53 ± 0.63
Toxicant (1 mol/L CCl₄)	33.06 ± 114	50.20 ± 0.61	57.50 ± 0.94
Std Liv52 (250 μL/mL)	85.84 ± 1.19 (86.7)^a	19.46 ± 0.35 (97.59)^a	24.10 ± 0.37 (92.85)^a
ALE (250 μg/mL)	57.63 ± 1.58 (40.39)^a	41.33 ± 0.62 (28.16)^a	44.53 ± 1.25 (36.05)^a
ALE (500 μg/mL)	77.60 ± 0.57 (73.72)^a	38.50 ± 0.45 (37.14)^a	32.80 ± 0.65 (68.66)^a
ALE (1000 μg/mL)	81.24 ± 1.67 (79.20)^a	22.23 ± 0.50 (88.48)^a	27.33 ± 0.69 (83.87)^a

Values in brackets indicate percentage protection against toxicant. Significant reduction compared to hepatotoxin (^aP < 0.05). ALT: Alanine aminotransferase; AST: Aspartate aminotransferase.

Citation: Pradeep HA, Khan S, Ravikumar K, Ahmed MF, Rao MS, Kiranmai M, Reddy DS, Ahamed SR, Ibrahim M. Hepatoprotective evaluation of Anogeissus latifolia: In vitro and in vivo studies. World J Gastroenterol 2009; 15(38): 4816-4822
URL: https://www.wjgnet.com/1007-9327/full/v15/i38/4816.htm
DOI: https://dx.doi.org/10.3748/wjg.15.4816