Long-term treatment with proton pump inhibitor is associated with undesired weight gain

Table 3 Mean changes in nutritional parameters and blood pressure at the last visit compared to the baseline

	Patients (n = 52)	Control (n = 58)	P
Body weight (kg)	+2.2b	-0.1a	< 0.0001
Body mass index (kg/m2)	+0.92b	+0.15a	0.0005
Blood pressure (mmHg)			-
Systolic	+2.7	+1.9	NS
Diastolic	-0.6	-1.9	NS
Serum total protein (g/dL)	+0.014	+0.019	NS
Serum total cholesterol (mg/dL)	-9.1	-17.1	NS
Serum Triglyceride (mg/dL)	+3.1	+3.8	NS

^aNS vs baseline;

^bP < 0.0001 vs baseline; NS: Not significant.