Long-term treatment with proton pump inhibitor is associated with undesired weight gain

Table 1 Baseline demographics and characteristics of reflux patients treated with long-term daily maintenance proton pump inhibitor therapy and healthy controls (mean ± SD)

	Patients	Control	P
Number of subjects	52	58	-
Gender (male/female)	36/16	38/20	NS
Age (yr)	68.1 ± 10.4	68.8 ± 1.5	NS
Duration of observation (yr)			NS
PPI therapy	2.1 ± 1.1	-	-
Medical checkup	-	2.0 ± 0.4	-
Body weight (kg)	56.4 ± 10.4	58.6 ± 8.4	NS
Height (cm)	156.0 ± 9.8	156.0 ± 8.9	NS
Body mass index (kg/m2)	23.1 ± 3.1	24.1 ± 2.7	NS
Blood pressure (mmHg)			-
Systolic	133 ± 17	132 ± 16	NS
Diastolic	75 ± 11	75 ± 9	NS
Serum total protein (g/dL)	7.2 ± 0.3	7.2 ± 0.3	NS
Serum total cholesterol (mg/dL)	210 ± 39	210 ± 25	NS
Serum triglyceride (mg/dL)	121 ± 52	107 ± 43	NS

PPI: Proton pump inhibitor.