Clonality and allelotype analyses of focal nodular hyperplasia compared with hepatocellular adenoma and carcinoma

doi:10.3748/wjg.15.4695

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Oct 7, 2009; 15(37): 4695-4708
Published online Oct 7, 2009. doi: 10.3748/wjg.15.4695

Table 2 Clinicopathological features of 12 HCAs and 22 HCCs, with data of clonality and LOH assays

Case numbers	Age (yr)/gender	Lesion codes	Lesion sizes (cm)	Lesion types	Ki-67-LI (%)	p53-LI (%)	Clonality by XCIA	No. of LOH	Chromosomal arms affected by LOH
11	36/F	HCA01	3.5	HCA	1.3	0	MC¹	3	8p, 11p, 16q
12	57/F	HCA02	3.0	HCA²	1.3	0	MC¹	1	17p
13	28/M	HCA03	7.3	HCA, SCC²	2.5	0	NT	4	11p, 13q, 17p
14	52/M	HCA04	8.5	HCA	1.1	0	NT	3	11p, 17p
15	31/F	HCA05	7.0	HCA	3.1	0	MC¹	4	11p, 13q
16	29/F	HCA06	1.0	HCA²	2.0	0	MC¹	NT	NT
		HCA07	12.0	HCA²	1.8	0	MC¹	5	1p, 13q, 17p
17	30/F	HCA08	1.0	HCA, SCC²	1.5	0	MC³	1	13q
18	29/F	HCA09	5.0	HCA	0.9	0	MC¹	4	6q, 11p, 13q, 17p
19	37/F	HCA10	5.0	HCA	1.3	0	MC³	2	13q, 17p
20	33/F	HCA11	2.0	HCA²	2.3	0	MC¹	NT	NT
21	40/F	HCA12	1.5	HCA²	2.0	0	MC³	NT	NT
22	31/F	HCC01	2.2	HCC, G1	2.0	10	NT	11	8p, 11p, 13q, 16q, 17p
23	46/M	HCC02	4.1	HCC, G1	65.0	0	NT	7	6q, 13q, 16q, 17p
24	42/M	HCC03	3.0	HCC, G1	2.5	0	NT	10	6q, 8p, 13q, 17p
25	51/M	HCC04	5.3	HCC, G1	8.2	80	NT	5	8p, 11p, 13q, 16q, 17p
26	49/M	HCC05	2.0	HCC, G1	2.0	0	NT	2	1p, 11p
27	27/M	HCC06	2.5	HCC, G1	1.2	0	NT	2	8p, 11p
28	56/M	HCC07	3.3	HCC, G1	1.5	0	NT	0	None
29	38/F	HCC08	8.3	HCC, G1	18.0	0	MC¹	NT	NT
30	64/F	HCC09	3.6	HCC, G1	5.5	0	MC³	NT	NT
31	53/F	HCC10	9.5	HCC, G2	8.5	0	NT	3	8p
32	33/M	HCC11	8.0	HCC, G2	5.2	0	NT	5	6q, 11p, 17p
33	48/F	HCC12	5.2	HCC, G2	35.0	0	NT	4	6q, 8p, 16q
34	44/F	HCC13	4.2	HCC, G2	65.0	80	NT	12	8p, 11p, 13q, 16q, 17p
35	29/F	HCC14	3.6	HCC, G2	0.9	0	NT	2	1p, 11p
36	61/F	HCC15	4.5	HCC, G2	3.7	0	NT	6	6q, 13q, 16q, 17p
37	48/M	HCC16	5.0	HCC, G2	1.4	0	NT	3	6q, 11p, 17p
38	39/M	HCC17	4.0	HCC, G2	1.5	0	NT	0	None
39	39/M	HCC18	5.0	HCC, G2	1.2	0	NT	0	None
40	50/M	HCC19	2.0	HCC, G2	2.0	0	NT	8	8p, 11p, 13q, 17p
41	51/M	HCC20	7.4	HCC, G2	12.2	0	NT	1	11p
42	55/F	HCC21	2.5	HCC, G2	28.5	0	MC³	NT	NT
43	77/F	HCC22	5.6	HCC, G2	16.2	0	MC³	NT	NT

¹Noninformative at PGK locus and the data obtained by the assay on AR locus;

²Some small preneoplastic foci, composed of clear cells, identified in surrounding liver parenchyma;

³Tested on PGK locus. HCA: Hepatocellular adenoma; HCC: Hepatocellular carcinoma; MC: Monoclonality; NT: Not tested for its origin from a male patient (for HCA) or its evidently malignant phenotypes; SCC: Small-cell change.

Citation: Cai YR, Gong L, Teng XY, Zhang HT, Wang CF, Wei GL, Guo L, Ding F, Liu ZH, Pan QJ, Su Q. Clonality and allelotype analyses of focal nodular hyperplasia compared with hepatocellular adenoma and carcinoma. World J Gastroenterol 2009; 15(37): 4695-4708
URL: https://www.wjgnet.com/1007-9327/full/v15/i37/4695.htm
DOI: https://dx.doi.org/10.3748/wjg.15.4695