Molecular mechanism and functional consequences of lansoprazole-mediated heme oxygenase-1 induction

Figure 8 Effect of PI3K-inhibitors LY294002 and wortmannin on lansoprazole-induced HO-1 promoter activity in stable transfected cell lines. Representative images of three to six separate experiments are shown (A and B). Light emission (shown by the rainbow bars: blue, least intense; red, most intense) was measured in NIH3T3-HO-1-luc cells with the IVIS. Results are expressed as mean ± SD of three to six separate experiments compared to lansoprazole (control = HO-1 promoter activity of cells stimulated with 30 μmol/L lansoprazole = 100%) (C). ^aP < 0.05 vs lansoprazole alone.