Molecular mechanism and functional consequences of lansoprazole-mediated heme oxygenase-1 induction

Figure 7 Effect of PI3K inhibitors LY294002 and wortmannin on lansoprazole-induced HO-1 mRNA expression. After pretreatment with PI3K inhibitors for 20 min, endothelial cells were incubated with lansoprazole for 8 h. Representative Northern blotting analysis is shown (A and B). Results are expressed as mean ± SD of three to six separate experiments compared to lansoprazole (control = gene expression of cells stimulated with 50 μmol/L lansoprazole = 100%) (C). ^aP < 0.05 vs lansoprazole alone.