Molecular mechanism and functional consequences of lansoprazole-mediated heme oxygenase-1 induction

Figure 6 Effect of different MAPK inhibitors on lansoprazole-induced HO-1 mRNA expression. After pretreatment with ERK inhibitor PD098059 (A), JNK inhibitor SP600125 (B), or p38 inhibitors SB203580 and SB202190 (C) for 20 min, endothelial cells were incubated with lansoprazole for 8 h. The Northern blotting analysis shown is representative of three to six independent experiments.