Molecular mechanism and functional consequences of lansoprazole-mediated heme oxygenase-1 induction

Figure 3 Lansoprazole, but not ranitidine, decreased NADPH-dependent ROS formation in macrophages. This effect was reversed in the presence of CrMP. Measurements of lucigenin-enhanced chemiluminescence were performed. ^aP < 0.05 vs control; ^cP < 0.05 vs lansoprazole alone. Data are shown as mean ± SD of three to six separate experiments.