Overview of immunosuppression in liver transplantation

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Sep 14, 2009 (publication date) through Jan 3, 2025

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Sep 14, 2009; 15(34): 4225-4233
Published online Sep 14, 2009. doi: 10.3748/wjg.15.4225

Table 2 Common side effects of immunosuppressive agents

Drug	Adverse effects
Tacrolimus	Nephrotoxicity, neurotoxicity¹, diabetes¹, hyperkalemia, metabolic acidosis, hypertension, hyperlipidemia
Cyclosporine	Nephrotoxicity, neurotoxicity, diabetes, hyperlipidemia¹, hypertension¹, hyperkalemia, metabolic acidosis, gingival hyperplasia, hypertrichosis
MMF	Myelosuppression, gastrointestinal side effects, viral infections (CMV, HSV), spontaneous abortions in pregnant women
Sirolimus	Hyperlipidemia, myelosuppression, proteinuria, poor wound healing, pneumonitis, skin rash
Corticosteroids	Diabetes, hypertension, obesity, osteoporosis, avascular necrosis, growth retardation, Cushingoid features, psychosis, poor wound healing, adrenal suppression, cataracts

¹More common in respective agent. MMF: Mycophenolate mofetil; CMV: Cytomegalovirus; HSV: Herpes simplex virus.

Citation: Pillai AA, Levitsky J. Overview of immunosuppression in liver transplantation. World J Gastroenterol 2009; 15(34): 4225-4233
URL: https://www.wjgnet.com/1007-9327/full/v15/i34/4225.htm
DOI: https://dx.doi.org/10.3748/wjg.15.4225