Molecular determinants of the profibrogenic effects of endothelin-1 in pancreatic stellate cells

Figure 5 Regulation of ET-1 expression in PSC. PSC growing in 24-well plates were treated with PDGF (10 μg/L), IFN-γ (100 μg/L), CTGF (2 mg/L), TNF-α (10 μg/L), and TGF β1 (5 μg/L) for 48 h as indicated. Afterwards, supernatants were collected and subjected to EIA analysis of the ET-1 content. Data from six separate cultures were used to calculate mean ± SE; ^aP < 0.05 vs control cultures.