Copyright
©2009 The WJG Press and Baishideng.
World J Gastroenterol. Sep 7, 2009; 15(33): 4163-4169
Published online Sep 7, 2009. doi: 10.3748/wjg.15.4163
Published online Sep 7, 2009. doi: 10.3748/wjg.15.4163
Table 1 The glucose-stimulated insulin release (μIU) in response to fentanyl with different concentrations of naloxone (mean ± SD, n = 12 )
Fentanyl alone | Fentanyl + 0.1μg/mL naloxone | Fentanyl + 1μg/mL naloxone | ||||
Low glucose | High glucose | Low glucose | High glucose | Low glucose | High glucose | |
Control (0 ng/mL) | 62.33 ± 9.67 | 125.5 ± 22.04 | 62.33 ± 9.67 | 125.5 ± 22.04 | 62.33 ± 9.67 | 125.5 ± 22.04 |
I (0.3 ng/mL) | 54.75 ± 5.93a | 118.17 ± 16.81 | 54.33 ± 8.99 | 110.4 ± 15.69 | 61.5 ± 8.13 | 126.75 ± 16.48 |
II (3 ng/mL) | 47.75 ± 8.47b | 96.17 ± 14.17b | 45.92 ± 7.63b | 88.25 ± 11.22d | 59.75 ± 8.42 | 118.33 ± 21.09 |
III (30 ng/mL) | 39.67 ± 6.18b | 75.17 ± 13.57b | 36.33 ± 5.79b | 68.67 ± 11.99d | 61.08 ± 8.07 | 126.0 ± 15.54 |
Naloxone | 61.67 ± 9.16 | 120.3 ± 18.04 | 60.67 ± 9.15 | 123.0 ± 20.89 |
- Citation: Qian TL, Wang XH, Liu S, Ma L, Lu Y. Fentanyl inhibits glucose-stimulated insulin release from β-cells in rat pancreatic islets. World J Gastroenterol 2009; 15(33): 4163-4169
- URL: https://www.wjgnet.com/1007-9327/full/v15/i33/4163.htm
- DOI: https://dx.doi.org/10.3748/wjg.15.4163