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©2009 The WJG Press and Baishideng.
World J Gastroenterol. Aug 28, 2009; 15(32): 4028-4036
Published online Aug 28, 2009. doi: 10.3748/wjg.15.4028
Published online Aug 28, 2009. doi: 10.3748/wjg.15.4028
Table 4 Prevalence of HBx and core promoter mutations in samples with different clinical diagnosis
| Characteristics | n(%) in each clinical diagnosis | |||||||||
| CH (n = 61) | LC (n = 62) | HCC | Total (n = 171) | P | ||||||
| With LC (n = 12) | Without LC (n = 36) | All HCC (n = 48) | CH vs LC | CH vs All HCC | LC vs All HCC | CH vs LC vs All HCC | ||||
| Genotype B/C (%B) | 46/15 (75.4) | 44/18 (71.0) | 10/2 (83.3) | 26/10 (72.2) | 36/12 (75.0) | 126/45 (73.7) | NS | NS | NS | NS |
| BCP mutations | ||||||||||
| C1726A/T1727(C/T) | 24 (39.3) | 8 (12.9) | 4 (33.3) | 7 (19.4) | 11 (22.9) | 43 (34.1) | 0.002 | NS | 0.015 | 0.003 |
| T1753V | 11 (18.0) | 29 (46.8) | 2 (16.7) | 9 (25.0) | 11 (22.9) | 51 (40.5) | 0.015 | NS | 0.018 | 0.004 |
| A1762T | 12 (19.7) | 38 (61.3) | 6 (50.0) | 21 (58.3) | 27 (56.3) | 77 (61.1) | < 0.001 | < 0.001 | NS | < 0.001 |
| G1764A | 13 (21.3) | 38 (61.3) | 5 (41.7) | 21 (58.3) | 26 (54.2) | 77 (61.1) | < 0.001 | 0.0002 | NS | < 0.001 |
| C1766T | 1 (1.6) | 3 (4.8) | 1 (8.3) | 1 (2.8) | 2 (4.2) | 6 (4.8) | NS | NS | NS | NS |
| T1768A | 1 (1.6) | 2 (3.2) | 1 (8.3) | 2 (5.6) | 3 (6.3) | 6 (4.8) | NS | NS | NS | NS |
| A1762T/G1764A | 12 (19.7) | 37 (59.7) | 5 (41.7) | 21 (58.3) | 26 (54.2) | 75 (59.5) | < 0.001 | 0.0004 | NS | < 0.001 |
- Citation: Utama A, Purwantomo S, Siburian MD, Dhenni R, Gani RA, Hasan I, Sanityoso A, Miskad UA, Akil F, Yusuf I, Achwan WA, Soemohardjo S, Lelosutan SA, Martamala R, Lukito B, Budihusodo U, Lesmana LA, Sulaiman A, Tai S. Hepatitis B virus subgenotypes and basal core promoter mutations in Indonesia. World J Gastroenterol 2009; 15(32): 4028-4036
- URL: https://www.wjgnet.com/1007-9327/full/v15/i32/4028.htm
- DOI: https://dx.doi.org/10.3748/wjg.15.4028