Endotoxin receptor CD14 gene variants and histological features in chronic HCV infection

Table 5 Hepatitis activity (grading) and fibrosis (staging) in chronic hepatitis C-infected patients with regard to CD14 rs2569190 genotype (Hep-Net group) n (%)

	CD14 rs2569190 genotype				MAF	aP
	CC	CT	TT	aP
Hepatitis activity
Mild	19 (27.1)	35 (50.0)	16 (22.9)		0.479
Moderate	73 (32.2)	113 (49.8)	41 (18.1)	0.513b	0.435	0.359
Severe	17 (32.7)	22 (42.3)	13 (25.0)
Fibrosis
Absent	4 (57.1)	2 (28.6)	1 (14.3)		0.449
Mild	35 (28.9)	61 (50.4)	25 (20.7)
Moderate	44 (32.8)	63 (47.0)	27 (20.2)	0.928b		0.837
Marked	18 (27.7)	37 (56.9)	10 (15.4)		0.441
Cirrhosis	8 (36.4)	7 (31.8)	7 (31.8)

^aχ² test was applied to compare mild vs moderate and severe hepatitis activity, absent, mild vs moderate and marked fibrosis and cirrhosis;

^bC carriers vs TT.