Endotoxin receptor CD14 gene variants and histological features in chronic HCV infection

Table 3 Biochemical serum parameters and the number of patients with elevated parameters in chronic hepatitis C with regard to CD14 rs2569190 genotype (UMG group)

	CD14 rs2569190 genotype				MAF	2P
	CC	CT	TT	2P
AST (median, IQR)	21.0, 15.8-50.5	28.5, 17.0-52.3	32.0, 16.5-76.5
1Number of patients with elevated/normal AST	9/21	29/41	19/18	0.159a	0.588/0.481	0.082
ALT (median, IQR)	36.0, 25.8-85.5	46.5, 26.8-87.3	50.0, 34.5-153.5
1Number of patients with elevated/normal ALT	11/19	38/32	23/14	0.171a	0.583/0.462	0.044
γ-GT (median, IQR)	35.5, 13.8-58.8	27.0, 14.0-56.3	32.0, 15.5-53.5
1Number of patients with elevated/normal γ-GT	10/20	19/51	11/26	0.934a	0.513/0.531	0.781

AST: Aspartate aminotransferase. Upper normal limit is 19 U/mL for males, and 15 U/mL for females; ALT: Alanine aminotransferase. Upper normal limit is 23 U/mL for males, and 19 U/mL for females; γ-GT: γ-glutamyltransferase. Upper normal limit is 28 U/mL for males, and 18 U/mL for females; IQR: Inter-quartile range.

¹Markedly elevated serum activities of transaminases (> two-fold the upper normal limit) were considered;

²χ² test was applied;

^aC carriers vs TT. After stratification by age, all P-values were non-significant.