Secondary hepatic resection as a therapeutic goal in advanced colorectal cancer

doi:10.3748/wjg.15.3855

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Aug 21, 2009; 15(31): 3855-3864
Published online Aug 21, 2009. doi: 10.3748/wjg.15.3855

Table 3 Randomized trials comparing first-line chemotherapy with or without cetuximab or bevacizumab that report secondary resection rates

Study	n	Regimen	Response rate (%)	Resection rate (%)	R0 rate (%)	R0 rate in liver-only disease (%)	PFS (mo)
Cetuximab
CRYSTAL[37]	559	FOLFIRI	38.7	2.5	1.5	4.5	8.0
CRYSTAL[37]	559	FOLFIRI + cetuximab	46.9	6.0	4.3	9.8	8.9
Bevacizumab
Hurwitz et al[38]	411	IFL	34.8	< 2%	NR	NR	6.2
Hurwitz et al[38]	402	IFL + bevacizumab	44.8	< 2%	NR	NR	10.6
NO16966[39 40]	701	CT¹	49.0	4.9	NR	11.5	8.0
NO16966[39 40]	699	CT¹ + bevacizumab	47.0	6.3	NR	12.3	9.4

¹FOLFOX4 or XELOX. PFS: Progression-free survival in the study arm; FOLFIRI: Irinotecan plus infusional 5-fluorouracil/leucovorin (5-FU/LV); IFL: Irinotecan, fluorouracil, and leucovorin; CT: Chemotherapy.

Citation: Saif MW. Secondary hepatic resection as a therapeutic goal in advanced colorectal cancer. World J Gastroenterol 2009; 15(31): 3855-3864
URL: https://www.wjgnet.com/1007-9327/full/v15/i31/3855.htm
DOI: https://dx.doi.org/10.3748/wjg.15.3855