IL-10 and TNF-α promoter haplotypes are associated with childhood Crohn’s disease location

Table 7 Allele and genotype distribution of the TNF-α polymorphisms n (%)

Position2	Controls	CD
-1031 C > T
CC1	1 (1)	12 (11)
CT	39 (47)	45 (40)
TT	43 (52)	55 (49)
C	41 (25)	69 (31)
T	125 (75)	155 (69)
-863 A > C
AA	4 (5)	10 (10)
AC	22 (28)	32 (32)
CC	52 (67)	58 (58)
A	30 (19)	52 (26)
C	126 (81)	148 (74)
-857 T > C
TT	1 (1)	1 (1)
CT	14 (18)	17 (17)
CC	63 (80)	82 (82)
T	16 (10)	19 (10)
C	140 (90)	181 (90)
-308 A > G
AA	1 (1)	-
AG	27 (29)	29 (26)
GG	66 (70)	83 (74)
A	29 (15)	29 (13)
G	159 (85)	195 (87)
-238 A > G
AA	2 (2)	-
AG	7 (8)	11 (10)
GG	80 (90)	97 (90)
A	11 (6)	11 (5)
G	167 (94)	205 (95)

¹The homozygous -1031 CC is associated with an increased risk of disease (OR = 9.9, 95% CI: 1.3-78, P = 0.008);

²The homozygous -1031 CC is associated (P = 0.02) with the colonic region; the heterozygous -1031 CT is associated with the terminal ileum location (P = 0.03); the homozygous -308 GG (P = 0.008) and -238 GG (P = 0.05) with the upper digestive tract.