No association between phosphatase and tensin homolog genetic polymorphisms and colon cancer

Table 2 Associations of PTEN SNPs with colon cancer n (%)

SNP	Cases	Controls	Base model1			Full model2
			OR	95% CI	P	OR	95% CI	P
rs926091
CC	289 (69.1)	351 (72.8)	1.0			1.0
CT	122 (29.2)	122 (25.3)	1.18	0.87-1.60	0.61	1.12	0.79-1.60	0.73
TT	7 (1.7)	9 (1.9)	1.12	0.40-3.13	0.71	0.99	0.29-3.41	0.92
rs2299939
CC	270 (64.6)	325 (67.4)	1.0			1.0
CA	134 (32.1)	147 (30.5)	1.15	0.85-1.55	0.56	1.01	0.72-1.42	0.18
AA	14 (3.3)	10 (2.1)	1.96	0.82-4.66	0.25	2.13	0.84-5.38	0.11
rs2248293
TT	181 (43.3)	212 (44.0)	1.0			1.0
TC	196 (46.9)	210 (43.6)	1.04	0.78-1.39	0.21	1.04	0.47-1.45	0.52
CC	41 (9.8)	60 (12.4)	0.77	0.48-1.22	0.23	0.86	0.51-1.46	0.51
rs12357281
GG	353 (84.4)	408 (84.7)	1.0			1.0
GC/CC3	65 (15.6)	74 (15.3)	0.93	0.64-1.37	0.98	0.99	0.65-1.53	0.98

¹Base model adjusted for age, gender and race;

²Full model further adjusted for BMI, family history of colorectal cancer, NSAID use, and physical activity based on 328 cases and 390 controls;

³Only three cases and two controls were of genotype CC, so they were combined with the heterozygotes to ensure validity of model fit.