No association between phosphatase and tensin homolog genetic polymorphisms and colon cancer

Table 1 Descriptive characteristics of the CWRU/kentucky colon cancer genetic epidemiology study population

	Cases (n = 421 )	Controls (n = 483)	P1
Age2 (yr)	62.7 ± 10.6	57.6 ± 11.2	< 0.0001
Gender (%)
Female	214 (50.8)	307 (63.6)	0.0001
Male	207 (49.2)	176 (36.4)
Race (%)
Caucasian	394 (93.6)	450 (93.2)	0.3
African-American	22 (5.2)	21 (4.4)
Other	5 (1.2)	12 (2.5)
BMI34 (kg/m2)	29.2 ± 6.2	28.2 ± 6.0	< 0.0001
Family History35
Yes	94 (26.8)	72 (17.1)	0.0015
No	257 (73.2)	349 (82.9)
NSAID use36 (%)
Yes	235 (64.2)	306 (68.9)	0.18
No	131 (35.8)	138 (31.1)
Physical activity3 (%)
Vigorous	165 (42.7)	247 (53.8)	0.006
Moderate	106 (27.5)	98 (21.4)
Light	115 (29.8)	114 (24.8)

¹P-value of significance difference between cases and controls in a χ² test (discrete variables and genotypes) or t-test (continuous);

²Age (mean ± SD) at diagnosis for cases and age at recruitment for controls;

³Calculations based on cases and controls with available information;

⁴BMI (mean ± SD);

⁵Family history of first-degree relatives with colorectal cancer;

⁶NSAID: Yes = either ibuprofen or aspirin use in the last 6 mo.