Characterization of focal liver lesions with SonoVue®-enhanced sonography: International multicenter-study in comparison to CT and MRI

Table 3 Lesion character of target lesion: SonoVue®-enhanced sonography vs other imaging modalities and final reference diagnosis n (%)

	Unenhanced sonography	SonoVue®-enhanced sonography	CT and/or MRI	Histology	Final reference diagnosis
n	127	127	115	31	127
Benign	25 (19.7)	61 (48.0)	41 (35.7)	8 (25.8)	68 (53.5)
Hemangioma (typical)	10 (40.0)	11 (18.0)	12 (29.3)	1 (12.5)	10 (14.7)
Hemangioma (atypical)	5 (20.0)	16 (26.2)	12 (29.3)	1 (12.5)	19 (27.9)
Focal nodular hyperplasia	6 (24.0)	20 (32.8)	9 (22.0)	3 (37.5)	24 (35.3)
Hepatic adenoma	0	2 (3.3)	2 (4.9)	2 (25.0)	3 (4.4)
Regenerating or dysplastic nodules	1 (4.0)	2 (3.3)	1 (2.4)	0	2 (2.9)
Focal fatty accumulation	0	2 (3.3)	1 (2.4)	0	2 (2.9)
Focal fatty sparing	2 (8.0)	3 (5.0)	1 (2.4)	0	3 (4.4)
Cyst	0	0	0	0	0
Other benign	1 (4.0)	5 (8.2)	3 (7.3)	1 (12.5)	5 (7.4)
Malignant	25 (19.7)	57 (44.9)	38 (33.0)	21 (67.7)	55 (43.3)
Hepatocellular carcinoma	14 (56.0)	34 (59.7)	21 (55.3)	13 (61.9)	33 (60.0)
Cholangiocarcinoma	0	0	0	1 (4.8)	1 (1.8)
Hypervascular metastasis	2 (8.0)	9 (15.8)	4 (10.5)	2 (9.5)	7 (12.7)
Hypovascular metastasis	9 (36.0)	10 (17.5)	10 (26.3)	3 (14.3)	10 (18.2)
Other malignant lesion	0	4 (7.0)	3 (7.9)	2 (9.5)	4 (7.3)
Indeterminate	77 (60.6)	9 (7.1)	34 (29.6)	2 (6.5)	4 (3.2)

CT: Computed tomography; MRI: Magnetic resonance imaging.