Original Articles
Copyright ©2009 The WJG Press and Baishideng.
World J Gastroenterol. Jan 21, 2009; 15(3): 310-320
Published online Jan 21, 2009. doi: 10.3748/wjg.15.310
Table 2 Biological process of up-regulated genes by triglitazone in SNU-668 cells
TermCountPvalueGenes
Negative regulation of cellular process292.26E-04ANGPTL4, ZFHX1B, MXD4, CXCL1, GPNMB, CDKN1A, IRF1, SESN2, JAZF1, FTH1, IL6, SVIL, JARID1B, MN1, DDIT3, PPP1R15A, IER3, ARHGEF2, TNFAIP3, RHOB, PRDM1, QSCN6, BNIP3L, MAP4, NRG1, EREG, FAIM3, IL8, FST
Response to chemical stimulus201.91E-04CCL20, PLD1, STC2, APOE, DEFB1, PLAU, CXCL1, SEMA3C, SRXN1, CCL5, SOD2, HSPA6, STC1, CXCL2, NDRG1, DNAJB2, IL8, MVP, ECGF1, ARNT2
Chemotaxis80.009882707CCL20, PLD1, CXCL2, CXCL1, PLAU, IL8, ECGF1, CCL5
Negative regulation of cell proliferation90.009171778FTH1, IL6, MXD4, EREG, CXCL1, IL8, GPNMB, CDKN1A, QSCN6
Programmed cell death220.002544517SQSTM1, TNFRSF21, PPP1R15A, APOE, ANGPTL4, IER3, TNFAIP3, RHOB, TNFRSF10A, ROCK1, HIPK2, CDKN1A, BNIP3L, C10orf97, IL6, RRAGC, APP, PHLDA2, RIPK2, FAIM3, IL24, TRIB3
Development629.62E-06SERPINE2, CXCL1, PHGDH, EPC1, MSX1, IL6, SLC3A2, COL7A1, IFRD1, NAV1, LIF, IER3, ARHGEF2, RHOB, DHRS9, PKD1, VAT1, SEMA3C, QSCN6, ANPEP, LTBP4, EDG3, SOX9, SQSTM1, PTGS2, IGF2BP3, FBN1, DNER, IGFBP5, CTGF, ANGPTL4, APOE, ZFHX1B, CSPG2, IL11, KLF6, RRAGC, S100P, NDRG1, SVIL, PNMA1, DACT1, CYP1B1, WNT5A, MAFB, PDLIM7, LAMA4, CRMP1, PAPPA, CAMTA1, RUNX1, KRTHA4, EREG, GPR56, NRG1, FST, IL8, DCN, ECGF1, ARNT2, NRP1, ITGA2
Organelle organization and biogenesis280.005845300WASPIP, APOE, HIST1H1C, CXCL1, EPC1, SVIL, MICAL1, H2BFS, HIST2H2AA, FMNL2, TINF2, PLEC1, TUBA1, HIST2H2BE, ARHGEF2, RHOF, ROCK1, TMOD1, HIST1H2BK, RHOB, SLC22A4, FSCN1, HIST1H2BD, ATG4A, KIF1A, MAP4, ECGF1, KLHL5
Inflammatory response120.002509065CCL20, PTGS2, CXCL2, PLA2G4C, CEBPB, EDG3, CXCL1, RIPK2, IL8, TNFAIP6, IRAK2, CCL5
Organ development210.003134980FBN1, ANGPTL4, PDLIM7, RHOB, PHGDH, IL11, ANPEP, MSX1, IL6, KLF6, SVIL, EREG, GPR56, SOX9, DCN, IL8, ECGF1, CYP1B1, NRP1, ITGA2, IFRD1
Transcription from RNA polymerase II promoter170.024568720SQSTM1, TRAK1, TSC22D1, DDIT3, MAFF, MXD4, IRF1, PRDM1, ATBF1, JAZF1, SOD2, FOXF1, NFIL3, RUNX1, STAT5A, CEBPB, SOX9
Cellular morphogenesis120.016732354KLF6, RRAGC, CTGF, IGFBP5, APOE, LTBP4, ARHGEF2, SLC3A2, VAT1, NRP1, QSCN6, EPC1
Blood vessel morphogenesis70.002345097ANPEP, ANGPTL4, EREG, RHOB, IL8, ECGF1, NRP1
Response to wounding202.23E-04CCL20, PTGS2, CTGF, PLA2G4C, PLAU, CXCL1, TNFAIP6, CCL5, SOD2, IL11, CXCL2, CEBPB, EREG, EDG3, RIPK2, FAIM3, IL8, SERPINE1, IRAK2, ITGA2
Apoptosis220.002437855SQSTM1, TNFRSF21, PPP1R15A, APOE, ANGPTL4, IER3, TNFAIP3, RHOB, TNFRSF10A, ROCK1, HIPK2, CDKN1A, BNIP3L, C10orf97, IL6, RRAGC, APP, PHLDA2, RIPK2, FAIM3, IL24, TRIB3
Cell-cell signaling242.63E-04CCL20, PBEF1, STC2, APOE, STX1A, LIF, GDF15, MAOA, TNFAIP6, GRB10, CCL5, IL11, STC1, GABARAPL1, IL6, LTBP4, EREG, GPR56, EFNA1, FST, IL8, ECGF1, NRP1, WNT5A
Response to stress350.003636369SQSTM1, CCL20, PTGS2, ERRFI1, PLA2G4C, CTGF, ANGPTL4, APOE, CXCL1, CD83, SRXN1, TNFAIP6, CCL5, IL11, SOD2, HSPA6, IL6, CD55, CEBPB, DNAJB2, SERPINE1, CFB, PPP1R15A, DDIT3, DEFB1, PLAU, CXCL2, EREG, EDG3, RIPK2, FAIM3, IL8, ARNT2, IRAK2, ITGA2
Vasculature development70.002345097ANPEP, ANGPTL4, EREG, RHOB, IL8, ECGF1, NRP1
Regulation of cell proliferation166.45E-04PBEF1, LIF, MXD4, ARHGEF2, CXCL1, GPNMB, CDKN1A, QSCN6, IL11, IRS2, FTH1, IL6, EREG, EDG3, IL8, NRP1
Cell organization and biogenesis470.001133913SQSTM1, TRAK1, WASPIP, STX3A, IGFBP5, CTGF, APOE, HIST1H1C, CXCL1, DNAJC12, EPC1, GABARAPL1, KLF6, RRAGC, SVIL, LARP6, MICAL1, HIST2H2AA, H2BFS, SLC3A2, FMNL2, TINF2, PLEC1, STX1A, TUBA1, DUSP16, HIST2H2BE, STX11, RHOF, ARHGEF2, RHOB, HIST1H2BK, TMOD1, ROCK1, SLC22A4, VAT1, FSCN1, QSCN6, BET1, HIST1H2BD, ATG4A, KIF1A, LTBP4, MAP4, ECGF1, KLHL5, NRP1
Cell differentiation210.001730483SQSTM1, PTGS2, APOE, ANGPTL4, PDLIM7, SERPINE2, RHOB, DHRS9, PAPPA, IL11, ANPEP, IL6, KLF6, NDRG1, LTBP4, EREG, NRG1, ECGF1, ARNT2, NRP1, IFRD1
Behavior110.004559090CCL20, PLD1, CXCL2, APOE, MAOA, PI3, CXCL1, PLAU, IL8, ECGF1, CCL5
Angiogenesis70.001885665ANPEP, ANGPTL4, EREG, RHOB, IL8, ECGF1, NRP1
Nucleosome assembly70.007444314HIST1H2BD, HIST2H2AA, HIST2H2BE, H2BFS, HIST1H1C, HIST1H2BK, SLC22A4
Cell adhesion240.00542196CLDN12, CTGF, LAMA4, CSPG2, RHOB, PKD1, CLDN1, TNFAIP6, CCL5, TPBG, KIAA0319, APP, ITGA5, LPP, GPR56, VTN, NID2, MYO10, IL8, COL7A1, MSLN, NRP1, ITGA3, ITGA2
Morphogenesis278.06E-05IGF2BP3, IGFBP5, CTGF, ANGPTL4, APOE, EPC1, MSX1, KLF6, RRAGC, SLC3A2, WNT5A, IER3, ARHGEF2, DHRS9, PKD1, RHOB, VAT1, QSCN6, ANPEP, LTBP4, EREG, EDG3, IL8, DCN, ECGF1, NRP1, ITGA2
Taxis80.009882707CCL20, PLD1, CXCL2, CXCL1, PLAU, IL8, ECGF1, CCL5
Glutamine family amino acid metabolism50.007880038GLS, GCLC, GFPT2, ASS, ASNS