Transient and etiology-related transcription regulation in cirrhosis prior to hepatocellular carcinoma occurrence

Table 4 Over-representation of functional subsets in our list of 70 transcripts

Cell proliferation1(O = 7; E = 2.66; P = 0.012)	Regulation of cell migration (O = 2; E = 0.15; P = 0.009)	Blood vesseldevelopment (O = 3; E = 0.41; P = 0.007)	Lipid metabolism (O = 9; E = 3.55; P = 0.007)	Antigen processing and presentation (O = 3; E = 0.25; P = 0.001)	Acute inflammatory response (O = 4; E = 0.58; P = 0.002)	NADH dehydrogenase activity (O = 3; E = 0.36; P = 0.005)	Oxidoreductaseactivity (O = 3; E = 0.25; P = 0.001)
JAG1 (Hs.5908813)	JAG1 (Hs.590881)	JAG1 (Hs.590881)	CLU (Hs.436657)	HLA-A (Hs.181224)	CLU (Hs.436657)	NDUFA6 (Hs.274416)	CYP2E1 (Hs.12907)
IGFBP7 (Hs.479808)	PLG (Hs.143436)	PLG (Hs.143436)	CYP2J2 (Hs.152096)	HLA-B (Hs.77961)	ORM1 (Hs. 567311)	NDUFB10 (Hs.513266)	CYP2J2 (Hs.152096)
IL12RB2 (Hs.479347)		CUL7 (Hs.520136)	CYP3A4 (Hs.567254)	CD74 (Hs.591258)	ORM2 (Hs.522356)	NDUFS4 (Hs.528222)	CYP3A4 (Hs.567254)
PLG (Hs.143436)			HMGCS2 (Hs.59889)		STAT3 (Hs.463059)
TIMP1 (Hs.522632)			APOB (Hs.120759)
ARHGEF1 (Hs.438429)			HSD17B6 (Hs.524513)
CD74 (Hs.591258)			DPM1 (Hs.301898)
			LARGE (Hs.474667)
			CD74 (Hs.591258)

¹This transcript subset coding for proteins with a related function was identified by gene ontology with the GOTM tool;

²Significance of enrichment for the GO category between transcript number observed (O) and expected (E) in this cate gory;

³Hs. number: Unique transcript identifier.