Transient and etiology-related transcription regulation in cirrhosis prior to hepatocellular carcinoma occurrence

Table 1 Biological and clinical data from patients with cirrhosis alone, HCC-associated cirrhosis and controls

Patient1	Number	Male/Female	Age2	Pathology3	Etiology4	Metavir5
						A0	A1	A2	A3
A1 to A7	7	3/4	48.4 ± 3.2	CIR	ALC	0	4	1	2
A15 to A24	10	7/3	50.4 ± 7.5	CIR	ALC	0	8	2	0
PA1 to PA10	10	8/2	67.1 ± 8.0	CIR + HCC	ALC	2	5	3	0
PA21 to PA29	9	9/0	60.9 ± 8.2	CIR + HCC	ALC	1	7	1	0
V8 to V14	7	6/1	57.4 ± 8.9	CIR	HCV	0	2	4	1
V25 to V34	10	5/5	55.7 ± 16.0	CIR	HCV	0	5	3	2
PV11 to PV20	10	6/4	71.5 ± 5.1	CIR + HCC	HCV	0	1	6	3
PV30 to PV35	6	2/4	66.2 ± 9.5	CIR + HCC	HCV	0	1	3	2
CL1 to CL8	8	3/5	59.9 ± 15.9	No CIR, no HCC6	--	7	1	0	0
CL9 to CL18	10	2/8	49.5 ± 14.0	No CIR, no HCC6	--	9	1	0	0

¹HCC-free alcoholic cirrhosis; PA: Peritumoral alcoholic cirrhosis; V: HCC-free HCV cirrhosis; PV: Peritumoral HCV cirrhosis; CL: Control without any detectable fibrosis. Underlined samples were studied by microarray and qRT-PCR; No underlining, independent cohort of samples studied by qRT-PCR only.

²mean ± SD.

³CIR: Cirrhosis; CIR + HCC: Peritumoral cirrhosis.

⁴HCV: Hepatitis C virus infection; ALC: Alcoholism; --: None.

⁵From left to right, number of patients with a given score of inflammation A0-A3. Difference in METAVIR score in HCC-free cirrhosis between all V vs A patients, P = 0.17 (Mann and Whitney’s test); In peritumoral cirrhosis between all PV vs PA patients, P = 0.005.

⁶Histologically normal liver sampled at a distance from a benign liver tumor or from a metastasis of non-hepatic cancer.