Breastfeeding and genetic factors in the etiology of inflammatory bowel disease in children

Table 1 Clinical and epidemiological features of Crohn’s disease and ulcerative colitis

	CD	UC
Region of involvement	Any portion of gastrointestinal tract	Rectum and colon
Typical region of involvement	Ileum and colon	Rectum and extending proximally
Nature of inflammatory process	Segmental, transmural	Continuous, limited to mucosa
Extraintestinal manifestations	Oral aphthous ulcers, peripheral arthritis, erythema nodosum, digital clubbing, episcleritis, renal stones, and gallstones	Pyoderma gangrenosum, sclerosing cholangitis, chronic active hepatitis, and ankylosing spondylitis
Age at presentation	Bimodal; 1st peak in late teens; 2nd peak in late adulthood	Bimodal; 1st peak in late teens; 2nd peak in late adulthood
Gender difference	Women are slightly more likely than men to develop CD	Men are slightly more likely than women to develop UC