Association of Fas/Apo1 gene promoter (-670 A/G) polymorphism in Tunisian patients with IBD

Table 3 Incidence of (-670 A/G) Apo1/Fas gene polymorphism analyzed with respect to sex in IBD patients n (%)

ApoI/Fas	Controls (n = 100)	CD females (n = 55)	CD males (n = 50)	UC females (n = 42)	UC males (n = 17)
Genotypic frequencies
A/A	49 (49)	14 (25.45)a	17 (34)	12 (28.57)b	5 (29.41)
A/G	32 (32)	24 (43.64)	16 (32)	23 (54.76)c	7 (41.18)
G/G	19 (19)	17 (30.91)	17 (34)	7 (16.67)	5 (29.41)
Allelic frequencies
A	130 (70)	52 (47.27)	50 (50)	47 (55.95)	17 (50)
G	70 (35)	58 (52.73)	50 (50)	37 (44.05)	17 (50)

Fas genotypes were similar in controls of both sexes: 52 males and 48 females; χ² = 0.06, P = 0.8, two degrees of freedom;

^aχ² test of heterogeneity between CD females and controls (χ² = 8.15, two degrees of freedom, P corrected = 0.004) odds ratio for AA genotype is 0.36 (0.16 < OR < 0.77, CI = 95%);

^bχ² test of heterogeneity between UC females and controls (χ² = 5.04, two degrees of freedom, P corrected = 0.02) odds ratio for AA genotype is 0.42 (0.18 < OR < 0.96, CI = 95%);

^cχ² test of heterogeneity between UC females and controls (χ² = 6.46, two degrees of freedom, P corrected = 0.01) odds ratio for AG genotype is 2.57 (1.15 < OR < 5.76, CI = 95%).