Perianal disease, small bowel disease, smoking, prior steroid or early azathioprine/biological therapy are predictors of disease behavior change in patients with Crohn’s disease

Table 4 Summary of Cox regression model: factors affecting time to disease behavior change

	P-value	Hazard ratio	95% CI
Disease location	0.001
L1	0.023	2.13	1.11-4.08
L2	0.05	0.54	0.27-1.001
L3	Reference
Perianal disease
Yes	< 0.001	3.26	1.90-5.59
No	Reference
Steroid use
Yes	0.006	7.48	1.79-31.2
No	Reference
Early azathioprine use
Yes	0.005	0.46	0.27-0.79
No	Reference
Smoking status
Yes	0.032	1.79	1.05-3.05
No	Reference