Perianal disease, small bowel disease, smoking, prior steroid or early azathioprine/biological therapy are predictors of disease behavior change in patients with Crohn’s disease

Table 1 Clinical characteristics of patients with Crohn’s disease n (%)

	CD (n = 340)
Male/female	155/185
Age (yr)	38.1 ± 13.2
Age at presentation (yr)	28.7 ± 12.4
Duration (yr)	9.4 ± 7.5
Familial IBD	39 (11.4)
Location
L1	75
L2	99
L3	161
All L4	22
L4 only	5
Behavior at diagnosis
B1	198
B2	65
B3	77
Behavior change from B1 to B2/B3	61 (30.8)
Perianal disease	117 (34.4)
Frequent relapse	126 (37.1)
Arthritis	127 (37.5)
PSC	10 (2.9)
Ocular	17 (5.0)
Cutaneous	43 (12.6)
Steroid use	264 (77.6)
Azathioprine use	216 (63.5)
Azathioprine intolerance	36 (14.3)
Biological use	71 (20.9)
Surgery/reoperation	158 (46.5)/52 (32.8)
Smoking habits
No	151
Ex	36
Yes	153

L1: Ileal; L2: Colonic; L3: Ileocolonic; L4: Upper gastrointestinal disease; B1: Inflammatory; B2: Stenosing; B3: Penetrating disease behavior. IBD: Inflammatory bowel disease.