Gallbladder emptying in patients with primary sclerosing cholangitis

Table 1 Clinical characteristics of 20 patients with PSC and 10 healthy controls

Clinical characteristic	PSC patients (n = 20)	Healthy controls (n = 10)	P value
Gender
Male	70% (14/20)	50% (5/10)	NS
Female	30% (6/20)	50% (5/10)	NS
Age in years (± SD)	39 ± 10	47 ± 13	NS
Associated IBD	90% (18/20)	0
UC	85% (17/20)
CD	5% (1/20)
Liver cirrhosis	10% (2/20)	0
Treatment with UDCA	85% (17/20)	0
Cholangiographic distribution of PSC		-
Extra-and intrahepatic involvement	75% (15/20)
Intrahepatic changes	25% (5/20)
Duration of PSC in years	9.7 ± 5	-
Mean P-ALP (< 1.9 &mgr;kat/L)	7 ± 6	1 ± 0.3	P < 0.05
Mean P-ALT (< 0.76 &mgr;kat/L)	1.4 ± 1.2	0.4 ± 0.1	P < 0.05
Mean P-Bilirubin (< 26 &mgr;mol/L)	20 ± 14	10 ± 5	NS
Mean P-Albumin (36-45 g/L)	40 ± 6	39 ± 5	NS
Mean P-Cholesterol (3.9-7.8 mmol/L)	5 ± 01	5 ± 0.1	NS
Mean BMI
Male	25 ± 4	25 ± 2	NS
Female	25.5 ± 2.5	25 ± 5	NS

PSC: Primary sclerosing cholangitis; ALP: Alkaline phosphatase; ALT: Alanine aminotransferase; IBD: Inflammatory bowel diseases; UDCA: Ursodeoxycholic acid; UC: Ulcerative colitis; CD: Crohn’s disease; NS: Not significant; BMI: Body mass index.