Alcoholic liver disease and hepatitis C: A frequently underestimated combination

Table 2 Fibrosis progression in HCV and alcohol consumption from selected studies

No. of patients	Alcohol consumption	Results	Ref.
2235	0 g, < 50 g, > 50 g	> 50 g independent risk factor for fibrosis progression (P < 0.001)	[26]
6664	> 5/6 drinks (female/male), > 1 year	Higher risk of cirrhosis (35% vs 18 %)	[27]
176	> 40/60 g (female/male), > 5 years	Faster cirrhosis progression (58 % vs 10 %), 2-3 fold increased risk of developing cirrhosis	[29]
168	Low < 30, medium 30-80; high > 80 g/d, > 5 J	Alcohol consumption low/medium/high significantly different between non-cirrhotics (58%/27%/16%) and cirrhotics (76%/15%/9%) (P < 0.05)	[28]
234	Lifetime alcohol consumption	Cirrhotics have greater alcohol consumption than patients with hepatitis (240 g/wk vs 146 g/wk) (P = 0.02)	[30]
233	0, 25, 50, 75, 100, > 125 g	Weekly alcohol consumption correlates with serum HCV RNA levels and fibrosis score (P < 0.001)	[23]
702	0/175 g/d	HCV increases OR for cirrhosis from 1 to 15 (0 g), 9.2 to 147.2 (175 g)	[141]
1667	Subgroup: > 260 g/wk vs < 90 g/wk	Risk for cirrhosis increases by 3.6	[31]
636	> 80	RR for cirrhosis: HCV 7.8, HCV + alcohol 31.1	[32]