Peripheral T-lymphocyte subpopulations in different clinical stages of chronic HBV infection correlate with HBV load

Table 4 Multiple linear regression predicting peripheral blood T lymphocyte subpopulations (n = 422)

	CD3+ T lymphocytes			CD4+ T lymphocytes			CD8+ T lymphocytes			CD4+/CD8+ ratio
	β	SE	P	β	SE	P	β	SE	P	β	SE	P
Intercept	85.35	2.64		43.32	1.53		16.48	1.73		1.89	0.08
Serum HBV load (Log, copies/mL)1	-3.62	0.34	< 0.0001	-1.29	0.19	< 0.0001	1.80	0.22	< 0.0001	-0.1	0.01	< 0.0001
HBeAg2	-2.74	1.40	0.06	-1.95	0.81	0.01	3.42	0.92	< 0.001	-0.16	0.04	< 0.01
HBV pre-C region mutation3	-0.67	1.13	0.55	-2.79	0.66	< 0.0001	3.38	0.74	< 0.0001	-0.15	0.04	< 0.0001
Clinical stages of HBV infection4			0.014			< 0.0001			< 0.001			< 0.0001
Active	-4.19	1.34		-3.64	0.77		3.63	0.88		-0.19	0.04
Inactive carrier	-5.17	1.98		-3.55	1.15		4.93	1.30		-0.26	0.06
Age at HBV infection5 (yr)			0.038			< 0.001			0.37			< 0.001
8-20	-1.07	1.25		2.21	0.73		0.14	0.82		0.07	0.04
> 20	-3.55	1.49		2.35	0.86		-0.55	0.98		0.15	0.05
Unknown	2.51	2.17		3.18	1.25		-0.94	1.42		0.16	0.07
Maternal HBV infection status6	-3.23	1.21	< 0.01	-1.35	0.70	0.06	2.14	0.79	< 0.01	-0.08	0.04	0.03

The linear regression model was employed in multivariate analysis to assess the independent effects of variables on peripheral blood T lymphocyte subpopulation. β: Coefficients from the model; SE: Standard error;

¹Continuous variable;

²Reference group with positive HBeAg;

³Reference group without pre-C mutation;

⁴Reference group at tolerant stage;

⁵Reference group with the age < 8 years at HBV infection;

⁶Reference group without maternal HBV infection status.